libros de cátedra introducción la microbiología clínica horacio lopardo ( coordinador) facultad de ciencias exactas introducció la micr robiolo ogía línica. 20 Set. List of contexts by syntactic structures. On words · On functions. On words. Lemma. –, a, a ab abs, a latere, a nativitate Domini, Aaron, ab. seco, trabajo húmedo, y productos de limpieza estan asociadas al riesgo de reportar He called “impetigo sparsa” to eruptions in the.

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Glycosylation isomers are also common at the same site within a given cell type. Fusion proteins albumin of the invention can be used to enhance or inhibit antibody-dependent cellular cytotoxicity. Such methods are known in the art.

ES2500918T3 – Albumin fusion proteins and beta interferon – Google Patents

The polynucleotide encoding the therapeutic protein and albumin protein, once part 5 of the albumin fusion construct, may each be called “portion”, “region” or “moiety” of the albumin fusion construct. Aneurysms include, among others, desiccants, false aneurysms aneurysms, infected aneurysms, ruptured aneurysms, aortic aneurysms, cerebral aneurysms, coronary aneurysms, heart aneurysms, and iliac aneurysms 5. Other controlled release systems are discussed in the summary by Langer Science Suitable tungsten oxides include tungsten oxide IV and tungsten oxide VI.

Additionally, disorders which can be treated with fusion proteins of the invention include, among others, 5 hemangioma, arthritis, psoriasis, angiofibroma, atherosclerotic plaques, delayed wound healing, granulations, hemophilic joints, hypertrophic scars, nonunion fractures, syndrome Osler-Weber, pyogenic granuloma, scleroderma, trachoma and vascular adhesions. If the polypeptide is secreted, the medium will contain the polypeptide, with or without the cells the cells, are removed by filtration or centrifugation.

Preferably the subject is an animal, including, among others, animals such as cows, pigs, horses, chickens, cats, dogs etc. For example, as described in the Examples, one “expression cassette” comprising, or t consisting of, one or more of bumedo a polynucleotide encoding a impetigl protein of albumin 15 given, 2 a leader sequence, 3 a promoter region and 4 a transcription terminator, may be assembled into a convenient cloning huumedo and then passed to a mammalian expression. Such solid supports include, among mipetigo, glass, cellulose, polyacrylamide, nylon, polystyrene, polyvinyl chloride or polypropylene.

In addition, fusion proteins of the invention can be used as a marker or detector of a disease or disorder of the immune system. Complications associated with the stress of labor and delivery include premature rupture of the membranes, premature labor, post-term pregnancy, postmaturity, parturition progresses very slowly, fetal distress eg, abnormal heart rhythm fetal or maternalbreathing problems, and abnormal fetal positiondystocia, prolapsed cord, amniotic fluid embolism and abnormal uterine bleeding.

In imptigo cases, treatment, likely in combination with steroids, may be instituted immediately to help prevent subsequent complications. If and 35 vector is a virus, it may be packaged in vitro using an appropriate packaging cell line and then of transduced into host cells. Approximately 14 days after the initial injuryhumefo before the development of hypertrophic or keloid scar.


In a preferred embodiment, the invention provides an albumin fusion protein comprising, or alternatively consisting of, a therapeutic protein and a serum albumin protein encoded by a polynucleotide described in Table 2. Various delivery systems are known and can be used to administer a compound imeptigo the invention, eg encapsulation in liposomes, microparticles, microcapsules, recombinant cells capable of expressing the compound, receptor-mediated endocytosis see, e.

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Fusion proteins albumin of the invention can be used as agents to enhance the capacity of 35 immune response among individuals immunodeficient B cells such as, for example, an individual who has undergone a partial or complete splenectomy. Representative examples of other anti-angiogenic factors include: For example, cells resulting from the introduction of an expression construct can be grown to produce the desired polypeptide.

El fragmento de HA es la forma madura de HA. For example, several types of human interferon are glycosylated. Malignant and metastatic conditions that can be treated with the polypeptides of the invention include, among others, malignancies, solid tumors and cancers described herein and others known in the art for a review bumedo such disorders, see Fishman al. This parent sequence may be a parental full length protein used to derive the concrete construction, the mature portion a parent protein, a variant or fragment of a wild-type protein, or hujedo artificial sequence may be used to create the construction described.

Ischemia Myocardial include, among others, coronary disease such as angina pectoris, coronary aneurysm, coronary arteriosclerosis, coronary thrombosis, coronary vasospasm, myocardial infarction and myocardial stunning X of the row as template DNA.

Complexes molybdate, ammonium molybdate and suitable include hydrates, sodium molybdate and its hydrates, and potassium molybdate and its hydrates Diseases that could be treated using this method include central and peripheral diseases nervous system, neuropathies, or mechanical and traumatic disorders p. Therapeutic proteins, particularly those disclosed in Table 1, and nucleic acid sequences and amino acids are well known in the art and available in public databases such as databases for chemical abstraes p data.

The host cell into which they are expressed may modify the corresponding therapeutic proteins to the therapeutic protein portion of a fusion protein of albumin of the invention, in such a way that glycosylation at one or more sites is altered as a result of manipulation s of their nucleic acid sequence, or can be modified due to other conditions of their expression.

As minimum requirement for fusion proteins albumin of the present invention of the present invention can be 35 used as molecular weight markers on SDS-PAGE or column gel filtration molecular sieve using methods well known humeo those skilled in The technique. Vectors that use glutamine synthase GS or DHFR as selectable markers can be amplified in the presence h methionine sulfoximine drugs or methotrexate, respectively.

Therefore, administration of fusion proteins of the invention that can inhibit an immune response, particularly the proliferation, differentiation, or chemotaxis of T cells, may be an effective therapy in preventing autoimmune disorders.


The HA fragment is the mature form of HA. Por ejemplo, se puede analizar un efecto deseable en un cultivo celular.

Ejemplos de dichos trastornos hiperproliferativos incluyen, entre 55 otros: In one embodiment, the invention provides a polynucleotide encoding a fusion protein comprising albumin, or alternatively consisting of, a therapeutic protein and a serum albumin protein.

Furthermore, different host cells have 15 translational characteristic and specific mechanisms for processing and modification p. Fusion proteins albumin of the invention can be used to modulate hemostatic cessation of bleeding or thrombolytic clot dissolving.

A fusion protein albumin of the invention may also increase or decrease the differentiation or proliferation of embryonic stem cells, besides, as discussed above, hematopoietic lineage Cerebrovascular disorders include, inter alia, diseases of the carotid arteries, amyloid angiopathy 10, cerebral aneurysm, cerebral anoxia, cerebral arteriosclerosis, cerebral arteriovenous malformation, diseases of cerebral arteries, stroke, and cerebral thrombosis, carotid artery thrombosis sinus syndrome Wallenberg, cerebral hemorrhage, epidural hematoma, subdural hematoma, subarachnoid hemorrhage, cerebral infarction, cerebral ischemia including transientof subclavian steal syndrome, periventricular leucomalazia, vascular headache, cluster headache, migraine and vertebrobasilar insufficiency.

The nervous system disorders that can be treated with the compositions of the invention p. When necessary, the composition may also include a solubilizing agent and a local anesthetic such as lignocaine to ease pain at the site of injection. Fusion proteins albumin the invention may be useful as agents to enhance migration, phagocytosis, superoxide production, antibody dependent neutrophil, eosinophil and macrophage cellular cytotoxicity.

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Similarly, nerve and brain tissue could also be regenerated using fusion proteins of the invention for prliferar and differentiate nerve cells. The compounds of the invention may be formulated as neutral or salt forms. Herein a method of treating a disease disclosed or disorder indicated in column “Preferred Indication Y” of Table 1 comprising administering to a patient in which it is desired that 50 treatment prevention or amelioration a fusion protein albumin of the invention comprising the portion corresponding therapeutic protein to the therapeutic protein disclosed in the “therapeutic protein X” column of table 1 in the same row as the disease or disorder to be treated is indicated in column “” Indication preferred Y “in table 1 in an amount effective to treat, prevent or ameliorate the disease or disorder.

Such disorders include, among others, those described in “Biological Activities” section of this document. Effective doses may be extrapolated from curves 30 dose response assay systems derived from animal or in vitro models.

Alternatively, anti-angiogenic compositions, prepared as described above, may also be administered directly to the cornea. The ability of the fusion protein albumin to immunoprecipitate a particular antigen can be assessed by, for example, analysis Western blot.