Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.
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Typically, hydrotropes consist of a hydrophilic part and a hydrophobic part like surfactants but the hydrophobic part is generally too small to cause spontaneous self-aggregation. Sodium gluconate, Piperazine anhydrous hyddotropic L-ascorbic acid were purchased from Molychem, Mumbai, India.
Indian Pharmacopoeia, Goverment of India ministry of health and family Welfare.
LOD and LOQ were calculated as andrespectively, where is the slope of the calibration curve and is the standard deviation of response [ 10 ]. Precision was determined by studying the repeatability and intermediate precision.
To form a hydrotrope, an aromatic hydrocarbon solvent is sulfonated creating an aromatic sulfonic acid. Solubilisation studies were performed using various concentrations of hydrotropes like sodium citrate, sodium benzoate, etc.
However, many hydrotropes do not seem to selfaggregate at all, unless a solubilisate has been added. Indian Pharmacist ; 6: The solubility enhancement ratios for drug in different hydrotropic solutions were calculated and the results were shown in Table 7. Int J Pharm Sci Res ; 9 1: A saturated solution is one in which the solute is in equilibrium with solubklization solvent. The drug spectrum was shown in Fig. The lipophilic drug that reaches market requires a high dose to attain proper pharmacological action.
However, the term has been used in the literature to designate non-micelle-forming substances, either liquids or solids, organic or inorganic, capable of solubilizing insoluble compounds. A novel application of hydrotropic solubilizationindevelopment and validation of spectrophotometric method forsimultaneous estimation of paracetamol and diclofenac sodium in solid dosage form International Journal of Pharma and Bio Sciences ; 1 3: It can also be defined quantitatively as well as qualitatively.
Hydrotropic solubilization of poorly water-soluble drugs.
There was more than a 18? About 29, metric tons are produced i. Mixed hydrotropy in spectrophotometric analysis of poorly water-soluble drug. A Promising tool for solubility Enhancement”, Int J. Solid dispersion and syrup formulation of poorly water-soluble drug by hydrotropy. World Journal of Pharmaceutical Research ; 3 4: Application solubikization hydrotropic solubilization in extraction of active constituents from crude drugs in pharmacognosy field.
A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solutions by means other than micellar solubilization. View solubilizationn Google Scholar S. The results of qualitative solubility of Lumefantrine shown in Table 3 reveal that the drug is freely soluble in dichloromethane, ethyl acetate and chloroform.
Solubility enhancement of ibuprofen using hydrotropic agents.
The results of the study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method Table 2. Earlier, many techniques have been developed for enhancing solubility of drugs. It is used in muscular, skeletal, and joint disorders such as osteoarthritis and rheumatoid arthritis.
Pseudoephedrine Sulphate, Desloratidine shows maximum absorbance at resulting solutions were measured at All the peaks values were found to be near the standard values to confirm the purity of the drug molecule. Keeping this point in view, the present research work is focused to enhance solubility of Lumefantrine using hydrotropic solubilization technique. The intraday concentration of the drug was calculated on the same day at an interval of one hour, whereas the interday concentration of drug was calculated on three hydrotropc days, within the laboratory conditions [ 7 ].
This page was last edited on 27 Novemberat Hydrotropes or hydrotropic agents are molecules having planar hydrotropic structure brought into solution by a polar group. Solubility indicates the maximum amount of a substance that can be dissolved in a solvent at a given temperature.
Adenosine triphosphate ATP has been shown to be a hydrotrope able to prevent aggregation of proteins at normal physiologic concentrations and to be approximately an order of magnitude more effective than sodium xylene sulfonate in a classic hydrotrope assay.
Solubility is one of the important parameter to achieve desired sooubilization of drug in systemic circulation for pharmacological response to be shown. If exact solubilities are not known, the pharmacopoeia provides general terms to describe a given range.
The absorbances were recorded against respective reagent blanks at appropriate wavelengths.
Solubility enhancement techniques with special emphasis on hydrotrophy. Abstract Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities.
View at Google Scholar Y. The solution was then filtered through Whatman filter paper No.
Archived from the original PDF on Lumefantrine was found to be more soluble at lower pH indicating basic nature of drug.
Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. From the above solution 1, 2, 3, 4, 5 and 6 ml was taken and diluted upto 10ml with 0.
These include Potassium acetate 6. It only requires solubilizatiom the drug with the hydrotrope in water. Then, few mg by visual observation of fine powder of drug was transferred to the bottle. Titrimetric analysis method employed for determining equilibrium solubility at room temperature.
Aliquots of filtrate obtained were diluted with suitable quantity of required solvent and analyzed using UV spectrophotometer at nm.
International Journal of Pharmacology and Clinical Sciences ; 2 1: