Histophilosis, or Histophilus somni–associated disease, is a common disease in North American cattle. It also has been reported to occur sporadically in beef. Histophilus somni is a Gram-negative bacterium that is associated with a disease complex (termed histophilosis) that can produce several clinical syndromes. Histophilus somni (H. somni) is a Gram-negative bacterium currently classified as a member of the Hae- mophilus-Actinobacillus-Pasteurella group. Clinical.

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Radostits OM et al.

Management practices that minimize overcrowding and stress should be implemented. Detection of antigen specific for Domni. The potential for these organisms to infect other ruminant species indigenous to North America and to cause disease has not previously been investigated.

These include bacterial culture, serology, and immunohistochemistry. Commercial bacterins are available, but their efficacy is questionable.

Thin sections were cut from formalin-fixed, paraffin-embedded lung tissue samples, stained with hematoxylin and eosin HEand examined for evidence of microscopic lesions. The brain itself may also be swollen secondary to edema.

It is also harbored in their reproductive tracts and has been associated with reproductive failure in domestic sheep and cattle. Evidence of histophipus congestion and edema may be noted as well. My Dashboard Dashboard Sign out. National Center for Biotechnology InformationU. Most of the previous reports have presented information related to the isolation somi H.


Historically, the most common disease manifestation was TME but, in recent years, respiratory disease and myocarditis are becoming more prevalent.

Because this proposal is not fully accepted, we are using herein the more usual name, Haemophilus somnus. In the heart this can cause myocarditis with multiple infarcts, necrosis, and abscessation.

The 12 males M and 62 females F were approximately 8 mo to more than 4 y of age. Traduit par Docteur Sonni Messier. The authors thank all individuals who assisted with the capture of bighorn sheep and the hsitophilus and timely submission of samples evaluated histophilux this study.

Therefore, acute and convalescent titers are needed to make a definitive diagnosis which is often times impossible due to the rapid course of the disease. Microthrombi were detected in alveolar septa of most of the lungs, and 3 lambs had occasional vascular thrombi in the brain. Colonies of Gram-negative bacteria may be seen in thrombi.

Fecteau G, George LW: Siddaramppa S, Inzana TJ: The lesions from Histophilus somni infection in the lungs can not be simni from Mannheimia hemolytica or Pasteurella multocida. Metaphylaxis involves pre-treatment with antibiotics prior to clinical illness.

Histophilus somni

Bovine preputial isolates, from asymptomatic carriers, not expressing these proteins Pt are sensitive to killing by bovine complement, whereas isolates that express these IgBPs, such asare resistant to complement-mediated killing and are virulent Isolated DNA from each of the isolates was tested in a PCR procedure for the lktA gene, which codes for leukotoxin production and has been demonstrated by Fisher et al 23 to be associated with production of hemolysis on blood agar by Pasteurella histophklus Mannheimia strains.


Select a Country zoetis. Infectious meningo-encephalitis in cattle, caused by a Haemophilus -like organism. Canadian Veterinary Journal Isolates and produced profiles with similarity coefficient values near 1. Immunological characterization of the major outer membrane protein histophilis Haemophilus somnus. Biberstein 7 reported that H. Regardless of the clinical signs, the course of the disease is domni and most affected animals will die within 24 hours.

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The histopathologic findings in the pneumonic lungs of the bighorn sheep were more consistent with the more chronic pneumonia detected in the d bovine experiment and in clinical cases. The RFLP profiles for the isolates were identical Figure 3which is indicative of isolation of a single clone of H. However, there are no reports of H. The pathogenesis of TME involves a bacterial septicemia. The agent, identified later as H. It appears microscopically as a cocco-bacillus, is a facultative anaerobe, non-motile, and a non-spore-forming bacteria.