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The reaction was allowed to warm to room temperature overnight. THF was removed under reduced pressure and the crude product was purified by flash column chromatography to give 2- ethylamino 3-methoxypropyl methylpyrido[2,3- d]pyrimidin-7 8H -one 0.


Complete applications will include:. The active compounds can also be in microencapsulated form, if appropriate, with one or more of the above-mentioned excipients. Injectable Formulation The following formularioo are mixed to form an injectable formulation.

The Compound of Claim 25 where R 6 is heteroaryl optionally substituted with 1, 2, or 3 R 9 groups.

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Regardless of which structure or which terminology is used, each tautomer is included within the scope of the Invention. The Compound of Claim 41 where R 6 is heteroaryl optionally substituted with 1, 2, or 3 R 9 groups.

The following materials will need to be uploaded as part of your online application:. Following the examples disclosed herein, as well as that disclosed in the art, a person of ordinary skill in the art can determine the inhibitory activity of a compound of this invention. Malfunctions of cellular signaling have been associated with many diseases, the most characterized of which include cancer and diabetes. Some of the compounds of the invention may exist as tautomers.

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The aqueous phase was separated 052 washed with an additional amount of ethyl acetate 70 mL. The mixture of components can be 00552 in any order that provides for the requisite binding.

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The residue was purified on SiO 2 2: The Compound of Claim 25 where R 1 is optionally substituted alkyl or cycloalkyl. Typically, but not necessarily, fused-polycyclics share a vicinal set of atoms, for example naphthalene or 1,2,3,4-tetrahydro-naphthalene. Solid forms comprising 1-ethyl 2-methyl 1H-1,2,4-triazolyl pyridinyl -3,4-dihydropyrazino[2,3-b]pyrazin-2 formu,ario -one and a coformer. Specifically, R 1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, or optionally substituted heterocycloalkylalkyl.

Abbreviations and Definitions 17] The following abbreviations and terms have the indicated meanings throughout: MA in Latin American Studies.

Pharmaceutical compositions of 7- 6- 2-hydroxypropanyl pyridinyl trans methoxycyclohexyl -3,4-dihydropyrazino[2,3- B]pyrazin-2 1H -one, a solid form there of and methods of their use. BR Kind code of ref document: Specifically, R 6 is indol- 2-yl, indolyl, indolyl, indolyl, indolyl, indolyl, benzimidazolyl, benzimidazolyl, benzimidazolyl, benzimidazolyl, benzimidazolyl, benzofuran yl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzofuranyl, benzoxazolyl, benzoxazolyl, benzoxazolyl, benzoxazolyl, benzoxazolyl, benzoisoxazolyl, benzoisoxazolyl, benzoisoxazolyl, benzoisoxazolyl, or benzoisoxazolyl; each of which is optionally substituted with 1, 2, 3, 4, or 5 R groups.

Specifically, R 6 is thienyl, thienyl, pyrrolyl, furanyl, furanyl, pyrazolyl, pyrazolyl, pyrazolyl, thiazolyl, thiazolyl, isoxazolyl, imidazolyl, triazolyl, tetrazol yl, each of which is optionally substituted with one R 9 where R 9when present, is methyl, benzyl, cyano, phenyl, iV-tert-butoxycarbonyl, or chloro. Willamette University’s Department of History invites applications for a tenure-track position at the rank of Assistant Professor beginning August The amount of a compound of the invention which constitutes a “therapeutically effective amount” will vary depending on the compound, the disease state and its severity, the age of the patient to be treated, and the like.


The Compound of Claim 29 where each R 9when present, is independently aryl, halo, alkoxy, aryloxy, and haloalkyl. The Compound of Claim 3 where R 1 is 00052 and R 4 is methyl.

Similarly, the connection between diabetes and related conditions, and deregulated levels of protein kinases, has been demonstrated.

The reaction mixture was heated to reflux for 2 h and then concentrated on a rotary evaporator to dryness. LCMS indicated complete conversion of starting material to product.

This reaction mixture was stirred for 3 h at room temperature. The protected derivatives of compounds of Formula I can be prepared by methods well known in the art.

This afforded ethyl 4-methyl methylthio oxo-l,6-dihydropyrimidinecarboxylate All references cited herein are incorporated by reference in their entirety.

The Compound of Claim 25 where R 6 is pyrazinyl, pyrimidinyl, or pyridazinyl each of which is optionally substituted with 1, 2, or 3 R 9 groups.