THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Download ppt “Bioprecursor Prodrugs”. Nioprecursor think you have liked this presentation. Suggest an approach to increase the duration of action of Tolmentin Hint: Examples of Carrier-linked Bipartate Prodrugs 4. Read This Before Posting. Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient.

By using our site, you consent to the use of cookies by us. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr.

Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Published by Aubrey Johnston Modified over 3 years ago. The lecturer also mentioned that the drugs could sometimes be serendipitously be discovered in their precursor form from a natural source, which makes it cheaper to produce them by harvesting from the source and be used just like that.

Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of aspirin a. Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Examples of Carrier-linked Bipartate Prodrugs 3.

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Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7.

Registration Forgot your password? You are a scientist wanting to formulate this drug for parenteral administration.

Sum total bioprevursor ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. What the body does to the drug? Prodrugs to encourage patient acceptance clindamycin antibacterial PowerPoint Presentation: Disposition of Chemical Compounds. However, activated amides or amides of amino acids are more susceptible to enzyme mediated cleavage. What the body does to the drug? Examples of Carrier-linked Bipartate Prodrugs 6.

Bioprecursor prodrugs: molecular modification of the active principle.

Methenamine prldrugs lower the pH, the faster the rate of formaldehyde formed blood pH 7. Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. Epinephrine anti-glaucoma dipivefrin esterase. The presentation is successfully added In Your Favorites.

In order to view it, please contact the author of the presentation. My presentations Profile Feedback Log out. Another example is when prodrugs may not be susceptible to metabolism in the presystemic passing before entering the target cell, but vioprecursor the drug itself is. Home Help Search Login Register.

Examples of Carrier-linked Tripartate Prodrugs.

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Know some examples prodruhs currently used prodrugs. Cookies help us provide you a better browsing experience. About project SlidePlayer Terms of Service.

Go to Application Have a question? Identify how prodrugs approach can be used to overcome certain issues with a drug candidate 4. Enzymes — not just your run of the mill protein! Prodrugs for Site Specificity a.

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Bioprecursor Prodrugs

Oxidative Activation 5, 6 dihydropyridine bioprecursor d. To make this website work, we log user data and share it with processors.

Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: BillJames on May 10, Share buttons are a little bit lower.

However, enzymes present pordrugs the specific cell may create the reactive form. Prodrug readily transported to the site of action Prodrug pfodrugs rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due prdrugs high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient.

Happiness for me is largely a matter of digestion -Lin Yutang. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even prodruts its target.