Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Doenja Hertog 1. Cases Series. Rui Henriques Martins Josias de Andrade Sobrinho AbrĂ£o Rapoport Marilene Paladino Rosa. Histopathologic features and management of .

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Plexiform pattern low power.

Clear cell variant which may contain clear PAS positive cells are localized in the stellate reticulum like areas. Rare malignant transformation has also been documented.

Community Dent Oral Epidemiol. Nevertheless, Feinberg and Steinberg 9 indicate different surgical margins for resections depending on the anatomical location and esthetic involvement. There are minimal areas of starry reticulum and in some regions ameloblasts are not evident. Ameloblastoma also occurs in long bones, and another variant is craniopharyngioma Rathke’s pouch tumour, pituitary ameloblastoma.

There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness ammeloblastoma ameloblastoma, however, this was only demonstrated in vitro. Dalati T, Zhou H. Cyst formation is common and ameloblast like areas are present only in small foci.

Another excluded patient was diagnosed with a metastasis of a previously treated cutaneous basal ameloblastmoa carcinoma, extending into the cortical bone of the mandible and mimicking an ameloblastoma. The annual incidence rates per million for ameloblastomas are 1.


Unicystic ameloblastoma luminal typeshowing ameloblastomatous epithelial lining the “cyst” wall H. Histopathologic changes in soft tissue associated with radiographically normal impacted third molars. There were no significant differences in the recurrence rate after enucleation in patients below and above the age of 20 years either.

It should be realised that a diagnosis of unicystic amoloblastoma may not always be easy to establish with certainty Malassez introduced the term adamantine epithelioma while Derjinsky introduced the term adamantinoma. Yet, amelioblastomas show more bone expansion and seldom show high density areas. Plexiform ameloblastoma with odontogenic epithelium arranged in the form of interlacing trabeculae and evidence of stromal degeneration.

The lesion has a tendency to expand the bony cortices because slow growth rate of the lesion allows time for periosteum to develop thin shell of bone ahead of the expanding lesion. Not declared Conflict of interest: Symptoms include painless swelling, facial deformity if severe enough, pain if the swelling impinges on other structures, loose teeth, ulcers, and periodontal gum disease. In order to prevent recurrence, we would suggest a safety margin of 1.

Photomicrograph depicting a typical follicular ameloblastoma with islands demonstrating peripheral columnar cells exhibiting reversal of polarity and central stellate-reticulum lie cells demonstrating cytic degeneration. This variant shows predominant basaloid pattern consisting of darkly stained cells with minimal cytoplasm and little evidence of palisading at the periphery resembling those seen in basal cell carcinoma. It shows equal sex predilection with no specific racial predominance.

Gorlin syndrome with ameloblastoma: Published online Dec 6.


In six of 17 patients with a recurrence, the primary lesion was typed different. Ameloblastoma with mucous cells: It presents clinically similar to a dentigerous cyst and is usually associated with an impacted tooth usually 3rd molars. Ameloblastoma usually occur sporadically without any apparent genetic predisposition. Treatment with radiation therapy and a case report”. Thus, wide surgical margins that are clear of disease are required for a good prognosis.


A Case Report and Review of Literature”. Unicystic ameloblastoma presenting as an unilocular radiolucency associated with an impacted mandibular third molar. The data of a total number of 44 patients were retrieved from the records.

Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia. In other projects Wikimedia Commons.

Ameloblastoma – Wikipedia

Other possible sources of origin include gingival surface epithelium and lining of odontogenic cysts. It typically presents radiographically as a mixed radiolucency and radiopacity mimicking a fibrosseous lesion. All patients in whom a preoperative diagnosis of ameloblastoma was available were advised to have radical surgery. Based on the clinical, radiographic, histopathologic and behavioral aspects, four subtypes of ameloblastoma are currently ameloblastoka namely: Age-standardized incidence rates of ameloblastoma and amepoblastoma cyst on the Witwatersrand, South Africa.

The ameloblastoma is a histologically almost always benign odontogenic tumour of the jaw bones.